Week Four

This week you will wrap up the Cell Energy theme by looking at the pathways of metabolism of fatty acids, amino acids and nucleotides. Then, the last session in the theme will describe how cells coordinate all of the metabolic and catabolic pathways you've covered so far.

The Cell Communication theme will continue with a description of how action potentials are generate and conducted along cell membranes. In addition, the theme will present some fundamental concepts in pharmacology, including pharmacokinetics and drug metabolism.

You will start the Life and Death of Cell theme by exploring the mechanisms of DNA replication and repair and discovering how cells respond to injury.

Lastly, the Public Health theme will explore study design and discuss the new systems approach to finding and eliminating medical errors.


Assignments to Completed Before Indicated Date

September 20, 2016

Read the paper for the Biochemistry Workshop, Mitochondrial Chain Respiratory Disorders (may require VPN): Mutation of the Mitochondrial Tyrosyl-tRNA Synthetase Gene, YARS2, Causes Myopathy, Lactic Acidosis, and Sideroblastic Anemia - MLASA Syndrome

Optional paper: The Role of Aminoacyl-tRNA Synthetases in Genetic Diseases

September 21, 2016

Read case and supporting material for Physiology Workshop on Receptor Function (see notes on BlueDogs and your iPads)

September 22, 2016

Complete the components of the Online Pharmacology Module titled How Are New Drugs Discovered? and Preclinical Studies. You can access the Online Pharmacology Module via this link (may need VPN): Online Pharmacology Module

September 23, 2016

Read cases and supporting material for EPH Workshop on Medical Errors (see notes on BlueDogs and your iPads)

Week Three

This week you will wrap up two themes: Building a Body and Gene Expression. Building a Body will conclude with the histology of Muscle and Blood Vessels, while Gene Expression will end by describing how proteins get to their proper location within cells and how cells deal with old, misfolded and unfolded proteins.

You will also start two themes this week. First, Cell Energy will describe the basic mechanisms of enzymes and the essential concepts in metabolism. Then, the theme will diagram the critical pathways through which cells convert sugars to chemical energy such as ATP. Cell Communication will also start this week by presenting the concepts, mechanisms and pathways in cell signaling and signal transduction. Then, the theme will introduce how we can manipulate some of these pathways with drugs. Lastly, the theme will explore the action potential, a critical means of cell communication in the nervous system.

Population Health will explore how public health agencies respond to population-wide emergencies and introduce the different methods used in study design.

The quiz for week two has been posted.


Assignments to Completed Before Indicated Date

September 12, 2016

Watch or read pre-session content for the Muscle Lab.

September 13, 2016

Watch or read pre-session content for the Blood Vessels Lab.

Read the papers for the Biochemistry Workshop, Carbohydrate Intolerance (may require VPN): Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans

September 14, 2016

Read case and supporting material for Physiology Workshop on Cystic Fibrosis (see notes on BlueDogs and your iPads)

September 15, 2016

Watch or read pre-session content for Cell Communication TBL

September 16, 2016

Read cases and supporting material for EPH Workshop on Primary Prevention (see notes on BlueDogs and your iPads)

Week Two

This week we'll continue with Building a Body by exploring the histology of Connective Tissue and Bone and the cellular structures and molecular mechanisms that are critical for muscle and blood vessels. The Gene Expression theme will pick up with RNA processing and translation and then introduce how genetic information is organized within genomes. In addition, the theme will describe some of the current methods used by researchers to changes the expression of genes in animal models. At the end of the week the Population Health theme will introduce some of the primary methods used to study disease on a population level, including incidence and prevalence.

Also, this week there will be two sessions from History of Medicine. History of Medicine will appear throughout the pre-clerkship curriculum to explore past incidents and trends that have shaped modern medicine. The first two sessions will focus on a problem that all of you will face: how to keep up with and incorporate (or not) into you practice all of the new discoveries made by researchers. On Wednesday afternoon, a lecture will introduce the some essential concepts and then you will work in small groups to discuss and analyze these concepts. Please check BlueDogs or you iPad for notes for the sessions and small group assignments.

The quiz for week one has been posted


Assignments to Completed Before Indicated Date

September 6, 2016

Watch or read pre-session content for Connective Tissue Lab

Read the papers for the Biochemistry Workshop, Emerging Infections (may require VPN)

September 7, 2016

Watch or read pre-session content for Bone Lab

September 8, 2016

Read case and supporting material for Physiology Workshop on Hypernatremia (on BlueDogs and your iPads)

September 9, 2016

Read cases and supporting material for EPH Workshop on Primary Prevention (on BlueDogs and your iPads)


Week One

We'll kick off the week with an introduction to Scientific Foundations and then we'll jump into the content of the course. We'll start with Building a Body and look at the four classes of macromolecules that compose all of the cells in our bodies. Then we will explore how these macromolecules assemble to form cells and how cells assemble into tissues. We'll end the week by introducing two of the four major types of tissue.

We'll also start the Fluids and Gradients theme which will describe the composition of the body's fluids and how cells establish and maintain a precise gradients of specific ions across their cell membranes. This concept is critical for understanding how every cell in the body functions.

On Friday, you'll start the Population Heath Theme. The two sessions will introduce concepts in public health and disease prevention and fundamental methods in descriptive epidemiology.


Please complete these assignments before the indicated dates

August 30, 2016

Watch or read pre-session content for Histological Features of Cells Lab

August 31, 2016

Watch and/or read the pre-session content for Cell to Tissues TBL

September 1, 2016

Watch and/or read the pre-session content for the Epithelia Lab

September 2, 2016

Read the following articles for the two EPH workshops on Friday (may require VPN if not a Yale network):