Week One Quiz

Click on the option to each question you think is correct

  1. Integral membrane proteins contain a domain that spans the cell membrane. The amino acids in that domain are most likely which of the following type?

    1. Hydrophilic
    2. Hydrophobic
    3. Polar
    4. Basic

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  2. Charcot-Marie-Tooth is a neurodegenerative which can be caused by the inability of motor neurons to move organelles from their cell bodies to the end of their very long axons. A mutation in which of the following genes would most likely cause this defect?/p>

    1. Actin
    2. Neurofilament
    3. Myosin
    4. Kinesin

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  3. Alport Syndrome is caused by mutations in a gene that encodes a type IV collagen. The disease mostly likely affects which of the following?

    1. Long bones
    2. Achilles tendon
    3. Kidney epithelium
    4. Knee cartilage

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  4. Oral rehydration therapy is a liquid designed to treat dehydration often caused by severe diarrhea. The liquid contains sodium to increase plasma sodium levels. Which of the following is also added to increase plasma sodium levels?

    1. Amino acids
    2. Glucose
    3. Potassium
    4. Calcium

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  5. You receive the results of your patients blood test which should normal levels of protein and potassium but a serum sodium concentration of 130 mmol/liter. What is the sodium concentration of your patient's interstitial fluid?

    1. 115 mmol/liter
    2. 127 mmol/liter
    3. 133 mmol/liter
    4. 147 mmol/liter

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  6. Which of the following might be an effective treatment for osteoporosis in women?

    1. Decrease expression of osteoprotegrin
    2. Decrease level of estrogen
    3. Decrease expression of RANK receptor
    4. Decrease level of phospate

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  7. The endosome is a membrane-bound organelle that receive material taken up from outside cells. Endosomes have an internal pH of about 6.0. Which change would you most likely expect in a protein that moved from interstitial fluid into an endosome?

    1. Become more positively charged
    2. Become more negatively charged
    3. Become more hydrophobic
    4. Become more hydrophilic

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  8. Which of the following best describes the sodium-potassium pump

    1. Increases intracellular sodium concentration
    2. Generated no net electrical current
    3. Generates net outward electrical current
    4. Generates net inward electrical current

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  9. Which of the following proteins is directly responsible for determining the leakiness of an epithelium?

    1. Claudins
    2. Cadherins
    3. Sodium-Glucose Transporter
    4. Potassium channel

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  10. In which of following circumstances would you be most likely to encounter a "cohort effect"

    1. A change in trends that affects rates across groups defined by year of birth and by age at the time of assessment.
    2. A change in trends associated with the introduction of a new and effective class of antibiotics that can be used in many age groups.
    3. A change in trends that results from a single group's lifetime experience, not limited to health-related exposures in the year of birth.
    4. A change in trends that occurs in a group irrespective of the year of birth and calendar time.
    5. A change in trends that results from a shift in reporting patterns for a common disease, such as a mild upper respiratory infection.

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  11. Geoffrey Rose is skeptical of the public health benefits of experimental and observational study designs. What is the basis of his skepticism?

    1. That comparisons should instead be made between cases drawn from one source population and controls drawn from a different source population.
    2. That variables that are determinative of health outcomes may be ubiquitous in a population.
    3. That experimental and observational studies are frequently poorly designed and implemented.
    4. That experimental and observational studies are used to assess differences in incidence between populations, when instead they should be used to assess differences between "patients" and "control" groups.

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